Membrane microdomain organization, calcium signal, and NFAT activation as an important axis in polarized Th cell function.

@article{Izspi2013MembraneMO,
  title={Membrane microdomain organization, calcium signal, and NFAT activation as an important axis in polarized Th cell function.},
  author={Emese Izs{\'e}pi and Leon{\'o}ra Himer and Orsolya Szil{\'a}gyi and P{\'e}ter Hajdu and Gy{\"o}rgy Panyi and Gl{\'o}ria L{\'a}szl{\'o} and J{\'a}nos Matk{\'o}},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2013},
  volume={83 2},
  pages={185-96}
}
T helper lymphocytes become polarized upon antigen and cytokine stimuli received after their maturation in the thymus. Since the balance of Th1 and Th2 responses is critical in healthy and pathological immune responses, understanding the molecular base of T cell polarization still remained an important question. Using our Th0/Th1/Th2 hybridoma model system, we performed a comparative study on polarized Th1 and Th2 cells in terms of their membrane raft expression/composition, their TCR mediated… CONTINUE READING