Membrane-localized activation of glucuronide prodrugs by β-glucuronidase enzymes

  title={Membrane-localized activation of glucuronide prodrugs by β-glucuronidase enzymes},
  author={K Chen and T-L Cheng and Y. L. Leu and Zeljko M. Prijovich and C-H Chuang and B M Chen and Steve R Roffler},
  journal={Cancer Gene Therapy},
Gene-mediated enzyme prodrug therapy (GDEPT) seeks to increase the therapeutic index of anti-neoplastic agents by promoting selective activation of relatively nontoxic drug derivatives at sites of specific enzyme expression. Glucuronide prodrugs are attractive for GDEPT due to their low toxicity, bystander effect in the interstitial tumor space and the large range of possible glucuronide drug targets. In this study, we expressed human, murine and Esherichia coli β-glucuronidase on tumor cells… CONTINUE READING
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