Membrane localization of small proteins in Escherichia coli.

@article{Fontaine2011MembraneLO,
  title={Membrane localization of small proteins in Escherichia coli.},
  author={Fanette Fontaine and Ryan T. Fuchs and Gisela Storz},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 37},
  pages={
          32464-74
        }
}
Escherichia coli synthesize over 60 poorly understood small proteins of less than 50 amino acids. A striking feature of these proteins is that 65% contain a predicted α-helical transmembrane (TM) domain. This prompted us to examine the localization, topology, and membrane insertion of the small proteins. Biochemical fractionation showed that, consistent with the predicted TM helix, the small proteins generally are most abundant in the inner membrane fraction. Examples of both N(in)-C(out) and N… CONTINUE READING

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