Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization.

@article{Liu2010MembraneLO,
  title={Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization.},
  author={Rui-Qin Liu and Qing-Hua Zhou and Shang-Rong Ji and Qiang Zhou and Du Feng and Yi Wu and Sen-Fang Sui},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 26},
  pages={
          19986-96
        }
}
beta-Amyloid peptide (Abeta42) is the core protein of amyloid plaque in Alzheimer disease. The intracellular accumulation of Abeta42 in the endosomal/lysosomal system has been under investigation for many years, but the direct link between Abeta42 accumulation and dysfunction of the endosomal/lysosomal system is still largely unknown. Here, we found that both in vitro and in vivo, a major portion of Abeta42 was tightly inserted into and a small portion peripherally associated with the lysosomal… CONTINUE READING
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