Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain.

Abstract

RasGRP1 is an exchange factor for membrane-localized Ras GTPases. Activation of RasGRP1 requires its translocation to membranes, which can be directly mediated by either its PT or C1 domains. RasGRP1 also has a pair of EF-hands which have been proposed to regulate RasGRP1 by sensing receptor-induced calcium fluxes. We determined that one of these EF-hands… (More)
DOI: 10.1016/j.bbamcr.2008.12.019

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