Membrane localization is critical for activation of the PICK1 BAR domain.

  title={Membrane localization is critical for activation of the PICK1 BAR domain.},
  author={Kenneth Lindegaard Madsen and Jacob Eriksen and Laura Milan-Lobo and D. S. Babcock ' B. K. Han and Masha Y. Niv and Ina Ammendrup-Johnsen and U. Henriksen and Vikram Kj\oller Bhatia and Dimitrios Stamou and Harald H. Sitte and Harvey T McMahon and Harel Weinstein and Ulrik Gether},
  volume={9 8},
The PSD-95/Discs-large/ZO-1 homology (PDZ) domain protein, protein interacting with C kinase 1 (PICK1) contains a C-terminal Bin/amphiphysin/Rvs (BAR) domain mediating recognition of curved membranes; however, the molecular mechanisms controlling the activity of this domain are poorly understood. In agreement with negative regulation of the BAR domain by the N-terminal PDZ domain, PICK1 distributed evenly in the cytoplasm, whereas truncation of the PDZ domain caused BAR domain-dependent… CONTINUE READING


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