Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH.

@article{Dainese2014MembraneLA,
  title={Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH.},
  author={Enrico Dainese and Gianni de Fabritiis and Annalaura Sabatucci and Sergio Oddi and Clotilde B Angelucci and Chiara Di Pancrazio and Toni Giorgino and Nathaniel H. Stanley and Michele Del Carlo and Benjamin F. Cravatt and Mauro Maccarrone},
  journal={The Biochemical journal},
  year={2014},
  volume={457 3},
  pages={
          463-72
        }
}
Lipid composition is expected to play an important role in modulating membrane enzyme activity, in particular if the substrates are themselves lipid molecules. A paradigmatic case is FAAH (fatty acid amide hydrolase), an enzyme critical in terminating endocannabinoid signalling and an important therapeutic target. In the present study, using a combined experimental and computational approach, we show that membrane lipids modulate the structure, subcellular localization and activity of FAAH. We… 
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