Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution.

@article{Alves2008MembraneIA,
  title={Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution.},
  author={Isabel D. Alves and Nicole Goasdou{\'e} and Isabelle Correia and Soline Aubry and C{\'e}cile Galanth and Sandrine Sagan and Solange Lavielle and G{\'e}rard Chassaing},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1780 7-8},
  pages={
          948-59
        }
}
Independently from the cell penetrating peptide uptake mechanism (endocytic or not), the interaction of the peptide with the lipid bilayer remains a common issue that needs further investigation. The cell penetrating or antimicrobial properties of exogenous peptides require probably different preliminary interactions with the plasma membrane. Herein, we have employed (31)P NMR, differential scanning calorimetry and CD to study the membrane interaction and perturbation mechanisms of two basic… CONTINUE READING
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