Membrane integration of in vitro-translated gap junctional proteins: co- and post-translational mechanisms.

@article{Zhang1996MembraneIO,
  title={Membrane integration of in vitro-translated gap junctional proteins: co- and post-translational mechanisms.},
  author={Jing Zhang and Maxine Chen and Cynthia I. Foote and Bruce J Nicholson},
  journal={Molecular biology of the cell},
  year={1996},
  volume={7 3},
  pages={471-82}
}
Connexins (Cx) are protein components of gap junction channels that permit the passage of small molecules between neighboring cells. cDNAs of a large family of connexins have been isolated and sequenced. A gap junction channel consists of two connexons, one from each cell in contact, composed of six connexin subunits. It has been suggested by Musil and coworkers that the oligomerization of formation of a connexon occurs at the level of the trans-Golgi network. In the present study, we initiated… CONTINUE READING

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