Membrane-induced structure of the mammalian tachykinin neuropeptide gamma.

  title={Membrane-induced structure of the mammalian tachykinin neuropeptide gamma.},
  author={Indu R Chandrashekar and Anjali Dike and Sudha M. Cowsik},
  journal={Journal of structural biology},
  volume={148 3},
Neuropeptide gamma (NPgamma) is a neurokinin-2 (NK-2) receptor selective agonist, which plays an important role in mediation of asthma and elicits a wide range of biological responses like bronchoconstriction, vasodepression and regulation of endocrine functions. The structure determination of this peptide agonist is important in understanding the molecular basis of peptide ligand recognition by the receptor and for rational drug design. In the present study we report the solution structure of… CONTINUE READING