Membrane-induced alterations in HIV-1 Gag and matrix protein-protein interactions.

  title={Membrane-induced alterations in HIV-1 Gag and matrix protein-protein interactions.},
  author={Suzanne F. Scarlata and Lorna S. Ehrlich and Carol A Carter},
  journal={Journal of molecular biology},
  volume={277 2},
The matrix (MA) domain of human immunodeficiency virus type 1 (HIV-1) contains sequences that direct association with the nucleus at early times in the virus replication cycle and with the plasma membrane at late times in the cycle. Localization to these sites is critical for functions related to the establishment of the infecting provirus and viral assembly, respectively. Mutational and structural analyses indicate that the opposing targeting signals which mediate these subcellular… CONTINUE READING