Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation.

@article{Brayden1990MembraneHI,
  title={Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation.},
  author={Joseph E. Brayden},
  journal={The American journal of physiology},
  year={1990},
  volume={259 3 Pt 2},
  pages={H668-73}
}
Acetylcholine (ACh)-induced hyperpolarization of cerebral arteries requires a functional endothelium. The hyperpolarization is reversed by potassium-channel blockers. The goal of this study was to determine whether the hyperpolarization is causally related to endothelium-dependent dilation of isolated cerebral arteries. ACh hyperpolarized rabbit middle cerebral arteries by up to 19 mV. The hyperpolarizations were sustained and did not occur in arteries without endothelial cells or in the… CONTINUE READING
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