Membrane guanylyl cyclase complexes shape the photoresponses of retinal rods and cones

@inproceedings{Wen2014MembraneGC,
  title={Membrane guanylyl cyclase complexes shape the photoresponses of retinal rods and cones},
  author={Xiao-Hong Wen and Alexander M Dizhoor and Clint L. Makino},
  booktitle={Front. Mol. Neurosci.},
  year={2014}
}
In vertebrate rods and cones, photon capture by rhodopsin leads to the destruction of cyclic GMP (cGMP) and the subsequent closure of cyclic nucleotide gated ion channels in the outer segment plasma membrane. Replenishment of cGMP and reopening of the channels limit the growth of the photon response and are requisite for its recovery. In different vertebrate retinas, there may be as many as four types of membrane guanylyl cyclases (GCs) for cGMP synthesis. Ten neuronal Ca(2+) sensor proteins… CONTINUE READING

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Membrane guanylyl cyclase complexes shape the photoresponses of retinal rods and cones

X-H Citation Wen, AM Dizhoor, CL Makino
Front. Mol. Neurosci. 7:45. doi: 10.3389/fnmol.2014.00045 This article was submitted to the journal Frontiers in Molecular Neuroscience • 2014

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