Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

Abstract

MOST patients with non-insulin-dependent diabetes mellitus are resistant to both endogenous and exogenous insulin1. Insulin resistance precedes the onset of this disease2 –4, suggesting that it may be an initial abnormality. Insulin-receptor kinase activity is impaired in muscle, fibroblasts and other tissues of many patients with non-insulin-dependent… (More)
DOI: 10.1038/373448a0

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