Membrane fusion of erythrocytes as a model study of the effects of muscle relaxants on presynaptic exocytosis.


The exact mechanism by which synaptic vesicles fuse with the presynaptic nerve terminal membrane has not been determined. We therefore investigated the effects of muscle relaxants on membrane fusion using the human red blood cell as a model membrane. The kinetics of calcium-phosphate-induced membrane fusion were monitored continuously by noting the relief… (More)