Membrane fusion mediated by herpesvirus glycoproteins: the paradigm of varicella-zoster virus.

@article{Cole2003MembraneFM,
  title={Membrane fusion mediated by herpesvirus glycoproteins: the paradigm of varicella-zoster virus.},
  author={Nancy L. Cole and Charles Grose},
  journal={Reviews in medical virology},
  year={2003},
  volume={13 4},
  pages={207-22}
}
Varicella-zoster virus (VZV) is well known for its propensity to cause polykaryons (syncytia) in the vesicles within infected skin. Similarly in cultured cells, VZV induces extensive syncytial formation by virus-mediated cell-to-cell fusion. Statistical analyses of fusion parameters demonstrated three-way interactive effects among all three tested variables (incubation temperature, cell type and virus strain). For example, fusion was greatly enhanced at 33 degrees C vs 37 degrees C; also fusion… CONTINUE READING