Membrane fusion induced by mutual interaction of the two charge-reversed amphiphilic peptides at neutral pH.

@article{Murata1991MembraneFI,
  title={Membrane fusion induced by mutual interaction of the two charge-reversed amphiphilic peptides at neutral pH.},
  author={Masayuki Murata and Satoshi Kagiwada and Sho Takahashi and Shun-ichi Ohnishi},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 22},
  pages={14353-8}
}
An anionic amphiphilic peptide and the charge-reversed cationic peptide are synthesized. They contain 20 amino acids with the same sequence except for 5 Glu residues for the anionic versus 5 Lys residues for the cationic peptides. Fusion of egg phosphatidylcholine large unilamellar vesicles is assayed with the fluorescent probes by the lipid mixing and the internal content mixing at neutral pH. The peptide mixture causes a rapid and efficient membrane fusion, in spite of no fusions with each… CONTINUE READING

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