Membrane excitability and excitation-contraction uncoupling in muscle fatigue.

  title={Membrane excitability and excitation-contraction uncoupling in muscle fatigue.},
  author={Michael Fauler and Karin Jurkat-Rott and Frank Lehmann-Horn},
  journal={Neuromuscular disorders : NMD},
  volume={22 Suppl 3},
High-frequency tetanic stimulation is associated with an increase in extracellular and T-tubular K(+) and changes of Na(+) and Cl(-) concentrations, membrane depolarization as well as inactivation of voltage-gated Na(+) channels. These alterations are expected to lead to fiber inexcitability, which is largely prevented by mechanisms intrinsic or extrinsic to muscle fibers. They act by adapting electrical membrane properties or by accelerating the reconstitution of ionic homeostasis. The high Cl… CONTINUE READING


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