Membrane estrogen receptor-α levels predict estrogen-induced ERK1/2 activation in MCF-7 cells

@article{Zivadinovi2004MembraneER,
  title={Membrane estrogen receptor-α levels predict estrogen-induced ERK1/2 activation in MCF-7 cells},
  author={Dragoslava Zivadinovi{\'c} and C. Scott Watson},
  journal={Breast Cancer Research},
  year={2004},
  volume={7},
  pages={R130 - R144}
}
We examined the participation of a membrane form of estrogen receptor (mER)-α in the activation of mitogen-activated protein kinases (extracellular signal-regulated kinase [ERK]1 and ERK2) related to cell growth responses in MCF-7 cells. We immunopanned and subsequently separated MCF-7 cells (using fluorescence-activated cell sorting) into mER-α-enriched (mERhigh) and mER-α-depleted (mERlow) populations. We then measured the expression levels of mER-α on the surface of these separated cell… CONTINUE READING
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Quantitative measurement of MAP kinase activation by estrogens via multiple signaling pathways

  • N Bulayeva, B Gametchu, CS Watson
  • Steroids
  • 2004
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