Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5.

@article{Ravula2017MembraneED,
  title={Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5.},
  author={Thirupathi Ravula and Carlo Barnaba and Mukesh Mahajan and G. M. Anantharamaiah and S C Im and Lucy A Waskell and Ayyalusamy Ramamoorthy},
  journal={Chemical communications},
  year={2017},
  volume={53 95},
  pages={12798-12801}
}
Heme's spin-multiplicity is key in determining the enzymatic function of cytochrome P450 (cytP450). The origin of the low-spin state in ferric P450 is still under debate. Here, we report the first experimental demonstration of P450's membrane interaction altering its spin equilibrium which is accompanied by a stronger affinity for cytochrome b5. These… CONTINUE READING