Membrane-embedded channel of bacteriophage phi 29 DNA-packaging motor for single molecule sensing and nanomedicine

Abstract

The genome of linear double-stranded DNA (dsDNA) viruses is packaged into a preformed procapsid fueled by ATP hydrolysis. The central channel component of the bacteriophage phi29 motor is a connector protein, which has been successfully inserted into a lipid bilayer and exhibited robust capability for extremely reliable and precise assessment of the… (More)

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