Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine.

@article{Harder1981MembraneEM,
  title={Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine.},
  author={David R. Harder and Peter W. Abel and Kent Hermsmeyer},
  journal={Circulation research},
  year={1981},
  volume={49 6},
  pages={1237-42}
}
To study the mechanism by which norepinephrine acts on vascular muscle cell membrane, we recorded membrane potential with intracellular microelectrodes in isolated cat basilar and pial arteries. On addition of norepinephrine concentrations less than 1 microM, pial arteries hyperpolarized and relaxed while basilar arteries depolarized and contracted. Relaxation and hyperpolarization of the pial arteries occurred without the need for addition of any other drug, which indicates the relaxation of… CONTINUE READING