Membrane dysfunction induced by in vitro ischemia in immature rat hippocampal CA1 neurons.

@article{Isagai1999MembraneDI,
  title={Membrane dysfunction induced by in vitro ischemia in immature rat hippocampal CA1 neurons.},
  author={Takeo Isagai and Naoko Fujimura and Eiichiro Tanaka and Satoshi Yamamoto and Hideho Higashi},
  journal={Journal of neurophysiology},
  year={1999},
  volume={81 4},
  pages={1866-71}
}
We investigated differences between immature and mature hippocampal neurons in their response to deprivation of oxygen and glucose (in vitro ischemia), using intracellular recording techniques from CA1 pyramidal neurons in rat brain slices. The membrane was more depolarized in immature hippocampal CA1 neurons (postnatal day 7, P7) compared with the adult neurons (P140), and the apparent input resistance in immature neurons was higher than that in adult neurons. In immature neurons, the… CONTINUE READING