Membrane dynamics in autophagosome biogenesis.

  title={Membrane dynamics in autophagosome biogenesis.},
  author={Sven R. Carlsson and Anne Simonsen},
  journal={Journal of cell science},
  volume={128 2},
Bilayered phospholipid membranes are vital to the organization of the living cell. Based on fundamental principles of polarity, membranes create borders allowing defined spaces to be encapsulated. This compartmentalization is a prerequisite for the complex functional design of the eukaryotic cell, yielding localities that can differ in composition and operation. During macroautophagy, cytoplasmic components become enclosed by a growing double bilayered membrane, which upon closure creates a… CONTINUE READING

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