Membrane dynamics and cell polarity: the role of sphingolipids.

  title={Membrane dynamics and cell polarity: the role of sphingolipids.},
  author={Dick Hoekstra and Olaf Maier and Johanna M van der Wouden and Tounsia Ait Slimane and Sven C D van IJzendoorn},
  journal={Journal of lipid research},
  volume={44 5},
In recent years, glycosphingolipids (GSLs) have attracted widespread attention due to the appreciation that this class of lipids has a major impact on biological life. Inhibition of the synthesis of glucosylceramide, which serves as a precursor for the generation of complex glycosphinglipids, is embryonic lethal. GSLs play a major role in growth and development. Metabolites of sphingolipids, such as ceramide, sphinganine, and sphingosine, may function as second messengers or regulators of… CONTINUE READING

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