Membrane disruptive antimicrobial activities of human β-defensin-3 analogs.

  title={Membrane disruptive antimicrobial activities of human β-defensin-3 analogs.},
  author={U S Sudheendra and Vishnu Dhople and Aritreyee Datta and Rajiv Kumar Kar and Charles E. Shelburne and Anirban Bhunia and Ayyalusamy Ramamoorthy},
  journal={European journal of medicinal chemistry},
Human beta defensin-3 (HβD-3) is a host-defense protein exhibiting antibacterial activity towards both Gram-negative and Gram-positive bacteria. There is considerable interest in the function of this protein due to its increased salt tolerance and activity against Gram-positive Staphylococcus aureus. In this study, analogs of HβD-3 devoid of N and C terminal regions are investigated to determine the influence of specific structural motif on antimicrobial activity and selectivity between Gram… CONTINUE READING
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