Membrane disposition of the M5-M6 hairpin of Na+,K(+)-ATPase alpha subunit is ligand dependent.

@article{Lutsenko1995MembraneDO,
  title={Membrane disposition of the M5-M6 hairpin of Na+,K(+)-ATPase alpha subunit is ligand dependent.},
  author={Svetlana Lutsenko and R Anderko and Jack H Kaplan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 17},
  pages={7936-40}
}
Extensive proteolytic digestion of Na+,K(+)-ATPase (EC 3.6.1.37) by trypsin produces a preparation where most of the extramembrane portions of the alpha subunit have been digested away and the beta subunit remains essentially intact. The fragment Gln-737-Arg-829 of the Na+,K(+)-ATPase alpha subunit, which includes the putative transmembrane hairpin M5-M6, is readily, selectively, and irreversibly released from the posttryptic membrane preparation after incubation at 37 degrees C for several… CONTINUE READING
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