Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

@article{Ratajczak2006MembranederivedMI,
  title={Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication},
  author={Janina Ratajczak and Marcin Wysoczynski and Friedrich A. von Hayek and Anna Janowska-Wieczorek and Mariusz Z Ratajczak},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={1487-1495}
}
Normal and malignant cells shed from their surface membranes as well as secrete from the endosomal membrane compartment circular membrane fragments called microvesicles (MV). MV that are released from viable cells are usually smaller in size compared to the apoptotic bodies derived from damaged cells and unlike them do not contain fragmented DNA. Growing experimental evidence indicates that MV are an underappreciated component of the cell environment and play an important pleiotropic role in… CONTINUE READING
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