Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats.

@article{Wellman2001MembraneDE,
  title={Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats.},
  author={George C. Wellman and L Cartin and Delrae M. Eckman and Andrea S Stevenson and Christine M Saundry and W. Jonathan Lederer and Mark T. Nelson},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 6},
  pages={H2559-67}
}
Elevated intracellular Ca(2+) ([Ca(2+)](i)) has been implicated in contractile and phenotypic changes in arterial smooth muscle during hypertension. This study examined the role of membrane potential and [Ca(2+)](i) in altered gene expression in cerebral arteries of a rat (Dahl) genetic model of salt-sensitive hypertension. Cerebral arteries from hypertensive animals (Dahl salt-sensitive) exhibited a tonic membrane depolarization of approximately 15 mV compared with normotensive (Dahl salt… CONTINUE READING
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