Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment

@article{Ramachandran2004MembranedependentCC,
  title={Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment},
  author={Rajesh Ramachandran and Rodney Ko Tweten and Arthur E. Johnson},
  journal={Nature Structural & Molecular Biology},
  year={2004},
  volume={11},
  pages={697-705}
}
Cholesterol-dependent cytolysins are bacterial protein toxins that bind to cholesterol-containing membranes, form oligomeric complexes and insert into the bilayer to create large aqueous pores. Membrane-dependent structural rearrangements required to initiate the oligomerization of perfringolysin O monomers have been identified, as have the monomer-monomer interaction surfaces, using site-specific mutagenesis, disulfide trapping and multiple fluorescence techniques. Upon binding to the membrane… CONTINUE READING
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