Membrane-delimited cell signaling complexes: Direct ion channel regulation by G Proteins

@article{Brown1993MembranedelimitedCS,
  title={Membrane-delimited cell signaling complexes: Direct ion channel regulation by G Proteins},
  author={Arthur M. Brown},
  journal={The Journal of Membrane Biology},
  year={1993},
  volume={131},
  pages={93-104}
}
Ion channels are signaling molecules and by them-selves perform no work. In this regard they are un like the usual membrane enzyme effectors for G proteins. The pathways of G protein receptor, G protein and ion channels are, therefore, purely infor mational in function. Because a single G protein may have several ion channels as effectors, the effects should be coordinated and this seems to be the case. Inhibition of Ca2+ current and stimulation of K+ currents would have a greater impact than… CONTINUE READING

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