Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.

Abstract

Fibrillar protein deposits (amyloid) in the pancreatic islets of Langerhans are thought to be involved in death of the insulin-producing islet beta cells in type 2 diabetes mellitus. It has been suggested that the mechanism of this beta cell death involves membrane disruption by human islet amyloid polypeptide (hIAPP), the major constituent of islet amyloid… (More)
DOI: 10.1073/pnas.0708354105

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