Membrane curvature and the control of GTP hydrolysis in Arf1 during COPI vesicle formation.

@article{Antonny2005MembraneCA,
  title={Membrane curvature and the control of GTP hydrolysis in Arf1 during COPI vesicle formation.},
  author={Bruno Antonny and Jo{\"e}lle Bigay and J-F Casella and Guillaume Drin and Bruno Mesmin and P. Gounon},
  journal={Biochemical Society transactions},
  year={2005},
  volume={33 Pt 4},
  pages={619-22}
}
The GTP switch of the small G-protein Arf1 (ADP-ribosylation factor 1) on lipid membranes promotes the polymerization of the COPI (coat protein complex I) coat, which acts as a membrane deforming shell to form transport vesicles. Real-time measurements for coat assembly on liposomes gives insights into how the GTPase cycle of Arf1 is coupled in time with the polymerization of the COPI coat and the resulting membrane deformation. One key parameter seems to be the membrane curvature. Arf-GAP1… CONTINUE READING

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