Membrane composition modulates prestin-associated charge movement.

  title={Membrane composition modulates prestin-associated charge movement.},
  author={John L. Sfondouris and Lavanya Rajagopalan and Fred A Pereira and William E. Brownell},
  journal={The Journal of biological chemistry},
  volume={283 33},
The lateral membrane of the cochlear outer hair cell (OHC) is the site of a membrane-based motor that powers OHC electromotility, enabling amplification and fine-tuning of auditory signals. The OHC membrane protein prestin plays a central role in this process. We have previously shown that membrane cholesterol modulates the peak voltage of prestin-associated nonlinear capacitance in vivo and in vitro. The present study explores the effects of membrane cholesterol and docosahexaenoic acid… CONTINUE READING
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Vertebrate Hair Cells

  • W. E. Brownell
  • 2006

2000)Cell andMolecular Biology of the Ear (Lim, D

  • W. E. Brownell, J. S. andOghalai
  • J., ed) pp
  • 2000

Membrane Composition Modulates Prestin Function

  • W. Rawicz, K. C. Olbrich, T. McIntosh, D. Needham, E. Evans
  • Biophys. J. 79,
  • 2000

The Cell: A Molecular Approach, 2nd Ed

  • G. M. Cooper
  • 2000

Membrane Composition Modulates Prestin Function 22480 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • J. Santos-Sacchi, S. Kakehata, S. Takahashi
  • J. Physiol
  • 1998

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