Membrane composition determines pardaxin's mechanism of lipid bilayer disruption.

  title={Membrane composition determines pardaxin's mechanism of lipid bilayer disruption.},
  author={Kevin J Hallock and Dong-kuk Lee and John R. Omnaas and Henry I. Mosberg and Ayyalusamy Ramamoorthy},
  journal={Biophysical journal},
  volume={83 2},
Pardaxin is a membrane-lysing peptide originally isolated from the fish Pardachirus marmoratus. The effect of the carboxy-amide of pardaxin (P1a) on bilayers of varying composition was studied using (15)N and (31)P solid-state NMR of mechanically aligned samples and differential scanning calorimetry (DSC). (15)N NMR spectroscopy of [(15)N-Leu(19)]P1a found that the orientation of the peptide's C-terminal helix depends on membrane composition. It is located on the surface of lipid bilayers… CONTINUE READING
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