Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster.

@article{Liszewski1991MembraneCP,
  title={Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster.},
  author={M. Kathryn Liszewski and Theodore W. Post and John P Atkinson},
  journal={Annual review of immunology},
  year={1991},
  volume={9},
  pages={431-55}
}
Membrane cofactor protein (MCP; CD46) is a widely distributed C3b/C4b-binding cell surface glycoprotein which serves as an inhibitor of complement activation on host cells. The protein has been purified, multiple cDNAs cloned and sequenced, and the genomic organization determined. MCP belongs to a family known as the regulators of complement activation (RCA) gene cluster. The RCA members are related structurally [possess approximately 60 amino acid repeating motifs termed short consensus… CONTINUE READING
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