Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation.

@article{Wang2000MembraneCP,
  title={Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation.},
  author={Guan Yong Wang and M. Kathryn Liszewski and Andrew Che-On Chan and John P Atkinson},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={
          1839-46
        }
}
Membrane cofactor protein (MCP; CD46) is a widely expressed type 1 transmembrane glycoprotein that inhibits complement activation on host cells. It also is a receptor for several pathogens including measles virus, Streptococcus pyogenes, Neisseria gonorrhea, and Neisseria meningitidis. That MCP may have signaling capability was suggested by its microbial interactions. That is, binding of MCP on human monocytes by measles virus hemagglutinin or cross-linking by an anti-MCP Ab resulted in IL-12… CONTINUE READING
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