Membrane cofactor protein (MCP, CD46) binding to clinical isolates of Streptococcus pyogenes: binding to M type 18 strains is independent of Emm or Enn proteins.

@article{Feito2007MembraneCP,
  title={Membrane cofactor protein (MCP, CD46) binding to clinical isolates of Streptococcus pyogenes: binding to M type 18 strains is independent of Emm or Enn proteins.},
  author={Mar{\'i}a Jos{\'e} Feito and Alejandra Sanchez and Maria Antonia Oliver and David P{\'e}rez-Caballero and Santiago Rodr{\'i}guez de C{\'o}rdoba and Sebasti{\'a}n Albert{\'i} and Jos{\`e} M Rojo},
  journal={Molecular immunology},
  year={2007},
  volume={44 14},
  pages={3571-9}
}
The complement regulatory protein CD46 (MCP, membrane cofactor protein) is used as a cell receptor by a number of bacterial and viral pathogens, including Streptococcus pyogenes (Group A Streptococci). The highly variable M (Emm) proteins are virulence factors of S. pyogenes, and Emm proteins of serotypes 5, 6 or 22 are able of binding to CD46, thus mediating the binding of Streptococci to human cells. In this work, using a soluble construction encompassing the extracellular domain of human… CONTINUE READING