Membrane cofactor protein (CD46) in seminal plasma is a prostasome-bound form with complement regulatory activity and measles virus neutralizing activity.

@article{Kitamura1995MembraneCP,
  title={Membrane cofactor protein (CD46) in seminal plasma is a prostasome-bound form with complement regulatory activity and measles virus neutralizing activity.},
  author={Masatsugu Kitamura and Masayuki Namiki and Kiyomi Matsumiya and Kazuyoshi Tanaka and Misako Matsumoto and Tomoko Hara and Hiroaki Kiyohara and Masashi Okabe and Akihiko Okuyama and Tsukasa Seya},
  journal={Immunology},
  year={1995},
  volume={84 4},
  pages={626-32}
}
Human seminal plasma contains 0.55 microgram/ml of membrane cofactor protein (MCP; CD46) of 60,000 MW. By ultracentrifugation, gel filtration and immunoelectron microscope methods, we found that the MCP in seminal plasma was associated with prostasomes. The functional properties of the prostasome-bound MCP were assessed in comparison with a recombinant soluble form, gamma MCP1, which is composed of four short consensus repeats (SCR), type C of the serine/threonine-rich domain (STC), and unknown… CONTINUE READING

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