Membrane cholesterol is a biomechanical regulator of neutrophil adhesion.

  title={Membrane cholesterol is a biomechanical regulator of neutrophil adhesion.},
  author={Hana Oh and Emile R. Mohler and Aiwei Tian and Tobias Baumgart and Scott L. Diamond},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={29 9},
OBJECTIVE The purpose of this study was to evaluate the role of membrane cholesterol on human neutrophil and HL-60 biomechanics, capture, rolling, and arrest to P-selectin- or IL-1-activated endothelium. METHODS AND RESULTS Methyl-beta-cyclodextrin (MbetaCD) removed up to 73% and 45% of membrane cholesterol from HL-60 cells and neutrophils, whereas MbetaCD/cholesterol complexes resulted in maximum enrichment of 65% and 40%, respectively, above control levels. Cells were perfused at a venous… CONTINUE READING
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