Membrane cholesterol is a biomechanical regulator of neutrophil adhesion.

Abstract

OBJECTIVE The purpose of this study was to evaluate the role of membrane cholesterol on human neutrophil and HL-60 biomechanics, capture, rolling, and arrest to P-selectin- or IL-1-activated endothelium. METHODS AND RESULTS Methyl-beta-cyclodextrin (MbetaCD) removed up to 73% and 45% of membrane cholesterol from HL-60 cells and neutrophils, whereas… (More)
DOI: 10.1161/ATVBAHA.109.189571

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Cite this paper

@article{Oh2009MembraneCI, title={Membrane cholesterol is a biomechanical regulator of neutrophil adhesion.}, author={Hana Oh and Emile R. Mohler and Aiwei Tian and Tobias Baumgart and Scott L. Diamond}, journal={Arteriosclerosis, thrombosis, and vascular biology}, year={2009}, volume={29 9}, pages={1290-7} }