Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling.

@article{Karnell2005MembraneCC,
  title={Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling.},
  author={Fredrick G. Karnell and Randall J Brezski and Leslie B. King and Michael A. Silverman and John Monroe},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 27},
  pages={25621-8}
}
Recent studies argue for an important role for cholesterol in maintaining plasma membrane heterogeneity and influencing a variety of cellular processes, including signaling, adhesion, and permeability. Here, we document that tolerance-sensitive transitional immature B cells maintain significantly lower membrane unesterified cholesterol levels than mature-stage splenic B cells. In addition, the relatively low level of cholesterol in transitional immature B cells impairs compartmentalization of… CONTINUE READING

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