Membrane-bound structure and energetics of alpha-synuclein.

  title={Membrane-bound structure and energetics of alpha-synuclein.},
  author={Maja Mihajlovic and Themis Lazaridis},
  volume={70 3},
Aggregation and fibrillation of alpha-synuclein bound to membranes are believed to be involved in Parkinson's and other neurodegenerative diseases. On SDS micelles, the N-terminus of alpha-synuclein forms two curved helices linked by a short loop. However, its structure on lipid bilayers has not been experimentally resolved. Using MD simulations with an implicit membrane model we show here that, on a planar mixed membrane, the truncated alpha-synuclein (residues 1-95) forms a bent helix… CONTINUE READING

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