Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.

@article{Driessen2003MembraneboundSC,
  title={Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.},
  author={Rebecca L Driessen and Heather M. Johnston and Susan K Nilsson},
  journal={Experimental hematology},
  year={2003},
  volume={31 12},
  pages={
          1284-91
        }
}
OBJECTIVE The transmembrane isoform of stem cell factor (tm-SCF) has been implicated in the adhesion of hemopoietic stem cells to the extracellular matrix within the bone marrow microenvironment in vitro. In addition, in vivo SCF has been shown to play a role in cell mobilization and migration. The aim of this study was to determine if SCF is an integral component of the hemopoietic "niche" of the bone marrow in situ. MATERIALS AND METHODS To analyze the role of tm-SCF in cell lodgment… CONTINUE READING
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