Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.

@article{Tger1997MembraneboundPI,
  title={Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.},
  author={Michael T{\"a}ger and Hendrick Kr{\"o}ning and Ute Thiel and Siegfried Ansorge},
  journal={Experimental hematology},
  year={1997},
  volume={25 7},
  pages={601-7}
}
The proteindisulfide isomerase (PDI), a multifunctional cytoplasmic enzyme with additional chaperone activity, has been shown recently, using monoclonal antibodies, to be located on the membrane of mature human B lymphocytes and B cell chronic lymphocytic leukemia (B-CLL) cells. Here, evidence is presented that this antigen exhibits catalytic activity as measured by the reductive degradation of insulin (release of A chain molecules) on intact B cells in patients suffering from B-CLL, as well as… CONTINUE READING

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