Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells

@article{Bafna2010MembraneboundMT,
  title={Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells},
  author={Sangeeta Bafna and Sukhwinder Kaur and Surinder K Batra},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={2893-2904}
}
Mucins (MUC) are high molecular weight O-linked glycoproteins whose primary functions are to hydrate, protect, and lubricate the epithelial luminal surfaces of the ducts within the human body. The MUC family is comprised of large secreted gel forming and transmembrane (TM) mucins. MUC1, MUC4, and MUC16 are the well-characterized TM mucins and have been shown to be aberrantly overexpressed in various malignancies including cystic fibrosis, asthma, and cancer. Recent studies have uncovered the… CONTINUE READING

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