Membrane-bound metallothionein 1 of murine dendritic cells promotes the expansion of regulatory T cells in vitro.

@article{Spiering2014MembraneboundM1,
  title={Membrane-bound metallothionein 1 of murine dendritic cells promotes the expansion of regulatory T cells in vitro.},
  author={Rachel Spiering and Jos{\'e}e P A Wagenaar-Hilbers and Veerle Huijgen and Ruurd van der Zee and Peter Johannes Sylvester van Kooten and Willem van Eden and Femke Broere},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2014},
  volume={138 1},
  pages={69-75}
}
Exposure to environmental toxicants can alter a range of cellular functions involved in the immune response. Increased expression of the stress protein metallothionein 1 (MT1) is one example hereof. Previously, it has been reported that MT1 has several immunosuppressive properties. Furthermore, we earlier showed that functionally tolerogenic dendritic cells (DCs) expressed increased mRNA levels of MT1. Here, we demonstrate that dexamethasone-treated murine DCs are functionally tolerogenic and… CONTINUE READING
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