Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

@article{GironMichel2005MembraneboundAS,
  title={Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.},
  author={Julien Giron-Michel and Massimo Giuliani and Manuela Fogli and Dani{\`e}le Brouty-Boy{\'e} and Silvano Ferrini and Florence Baychelier and Pierre Eid and Caroline Lebousse-Kerdil{\`e}s and Deniz Durali and Roberto Biassoni and Bernard Charpentier and Aim{\'e} Vasquez and Salem Chouaib and Anne Caignard and Alessandro Moretta and Bruno Azzarone},
  journal={Blood},
  year={2005},
  volume={106 7},
  pages={2302-10}
}
Membrane-bound and soluble interleukin-15 (IL-15)/IL-15 receptor alpha (Ralpha) complexes trigger differential transcription factor activation and functions on human hematopoietic progenitors. Indeed, human spleen myofibroblasts (SMFs) are characterized by a novel mechanism of IL-15 trans-presentation (SMFmb [membrane-bound]-IL-15), based on the association of an endogenous IL-15/IL-15Ralpha complex with the IL-15Rbetagamma c chains. SMFmb-IL-15 (1) induces lineage-specific signaling pathways… CONTINUE READING
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