Membrane bound O-acyltransferases and their inhibitors.

@article{Masumoto2015MembraneBO,
  title={Membrane bound O-acyltransferases and their inhibitors.},
  author={N. Masumoto and Thomas Lanyon-Hogg and U. R. Rodgers and Antonios D. Konitsiotis and A. Magee and E. Tate},
  journal={Biochemical Society transactions},
  year={2015},
  volume={43 2},
  pages={
          246-52
        }
}
Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes. 
22 Citations
Crystal structure of a membrane-bound O-acyltransferase
  • 38
Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.
  • 6
Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase
  • 12
  • PDF
...
1
2
3
...

References

SHOWING 1-10 OF 66 REFERENCES
Membrane-bound O-acyltransferases (MBOATs)
  • 33
Acyltransferases for secreted signalling proteins (Review)
  • 40
Large-scale profiling of protein palmitoylation in mammalian cells
  • 365
  • PDF
Ghrelin O-acyltransferase assays and inhibition.
  • 28
Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase*
  • 51
  • PDF
A small molecule antagonist of ghrelin O-acyltransferase (GOAT).
  • 39
  • PDF
Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine*
  • 64
  • PDF
...
1
2
3
4
5
...