Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70

@inproceedings{Xie2010MembraneboundHM,
  title={Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70},
  author={Yufeng Xie and O N Baĭ and Haifeng Zhang and Jinying Yuan and Sam Zong and Rajni Chibbar and Karen Slattery and Mabood Qureshi and Yangdou Wei and Yulin Deng and Jim Xiang},
  booktitle={Journal of cellular and molecular medicine},
  year={2010}
}
Exosomes (EXO) derived from tumour cells have been used to stimulate antitumour immune responses, but only resulting in prophylatic immunity. Tumour-derived heat shock protein 70 (HSP70) molecules are molecular chaperones with a broad repertoire of tumour antigen peptides capable of stimulating dendritic cell (DC) maturation and T-cell immune responses. To enhance EXO-based antitumour immunity, we generated an engineered myeloma cell line J558(HSP) expressing endogenous P1A tumour antigen and… CONTINUE READING
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